2026-04-30T21:28:51Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/3137 2021-12-13T05:48:34Z 1582963366982:1596631591423 user-um1

Catalase restores the altered mRNA expression of collagen and matrix metalloproteinases by dermal fibroblasts exposed to reactive oxygen species Zaw KK Yokoyama Y Abe M Ishikawa O <p>We investigated the effects of reactive oxygen species (ROS) on mRNA expression of&nbsp;proalphal (l) collagen, proalphal (lll) collagen, matrix metalloproteinases-1 (MMP-1), 72&nbsp;kDa type lV collagenase (MMP-2), and tissue inhibitor of metalloproteinase (TIMP-1) by&nbsp;normal human dermal fibroblasts in a novel three-dimensional culture. Fibroblasts&nbsp;exposed to ROS generated by the hypoxanthine-xanthine oxidase system revealed an&nbsp;increased mRNAexpression of MMP-1 and MMP-2 with a maximum at48 h and 72h after<br> exposure. A slight increase in the mRNA level of tissue inhibitor of metalloproteinase&nbsp;(TIMP-1) was observed.</p> 2006-10-18 http://hdl.handle.net/20.500.12678/0000003137 https://meral.edu.mm/records/3137