2026-04-17T08:37:21Z
https://meral.edu.mm/oai
oai:meral.edu.mm:recid/3126
2022-03-24T23:15:13Z
1582963366982:1597649530495
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Comparison of Serum Epidermal Growth Factor Receptor and Cyclooxygenase-2 Levels in Patients with Non-small Cell Carcinoma of Lung and Normal Subjects
Thuzar Kyin Aung
Htar Kyi Sunn
Theingi Myint
<p>Relation of inflammation and cancer can be proven in most of the studies. Epidermal growth factor receptor (EGFR) overexpression is one of the commonest causes of non-small cell carcinoma of lung cancer (NSCLC). Cyclooxygenase-2 (COX-2) enzyme and its products; prostaglandin, prostacyclin, thromboxane are involved in inflammation. The aim of the study was to compare the serum epidermal growth factor receptor and cyclooxygenase-2 levels between patients with non-small cell carcinoma of lung and healthy controls. This study included 53 patients diagnosed as NSCLC and 16 apparently healthy controls. In 53 patients, 3 patients were<br>
diagnosed as adenocarcinoma and 50 patients were diagnosed as squamous cell carcinoma (SCC) of lung. In both subjects, serum EGFR and COX-2 levels were determined by ELISA. The mean serum EGFR and COX-2 levels of NSCLC patients were significantly higher than those of healthy controls (170.10±13.80 vs. 3.56±0.48 ng/ml) and (13.21±3.17 vs. 0.62± 0.15 ng/ml), respectively (p<0.001 in both). Both the mean serum EGFR and COX-2 levels of SCC patients (172.10±14.30 ng/ml and 13.60±3.34<br>
ng/ml) were significantly higher than those of healthy controls (p<0.001 in both).</p>
2016-04-01
http://hdl.handle.net/20.500.12678/0000003126
https://meral.edu.mm/records/3126