2026-06-25T06:21:05Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/1921 2021-12-13T07:16:53Z 1582963390870:1582967633684 user-uy

Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar Nwet Nwet Win Awale, Suresh Esumi, Hiroyasu Tezuka, Yasuhiro Kadota, Shigetoshi The CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 lg/mL. Bioassayguided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC100) against PANC-1 cells under nutrientdeprived conditions at 1 lM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay. 2008 http://hdl.handle.net/20.500.12678/0000001921 https://meral.edu.mm/records/1921