2026-04-29T20:14:46Z https://meral.edu.mm/oai

oai:meral.edu.mm:recid/00007100 2021-12-13T01:04:59Z 1607990757259:1608059231712 user-udmy

The Efficacy of Locally Delivered Azadirachta indica (Neem) Extract Gel in Chronic Periodontitis Hnin Yu Lwin Zar Zar Linn Aung Kyaw Oo Tin Tun Hla The present study aimed to assess the efficacy of locally delivered Azadirachta indica (neem) extract gel as an adjunct to nonsurgical periodontal therapy in the management of chronic periodontitis. Plaque control in periodontics range from mechanical debridement of tooth surfaces by professional scaling and root planing and self-performed plaque removal to local and systemic delivery of chemical antimicrobial agents. In recent times, herbal products as novel drugs are tried in local drug delivery. Neem has multivarious actions like anti-microbial, antiseptic, anti-inflammatory properties. This study was conducted at the Department of Periodontology, University of Dental Medicine, Yangon. A total of 44 sites from 44 subjects with chronic periodontitis were included after obtaining a fully-formed consent and were randomly collected by balanced randomization method into two groups. Study group was treated by scaling and root planing with locally delivered neem extract gel whereas control group was treated by scaling and root planing alone. The clinical parameters [Plaque Index (PlI), Gingival Index (GI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL)] were recorded at baseline and 6th week after treatment. The results showed improvements in clinical parameters at both study and control sites. On comparison of clinical parameters at baseline and 6th week after treatment, a mean change of PPD of 1.79±0.04 in study group and 1.12±0.04 in control group were observed and statistically high significant difference (p<0.05). This study revealed that the adjunctive use of locally delivered neem extract gel has no known side effects and has promising results. 2020-12-30 http://hdl.handle.net/20.500.12678/0000007100 https://meral.edu.mm/records/7100